BIOSYNTHESIS OF ITACONIC ACID IN ASPERGILLUS TERREUS
نویسندگان
چکیده
منابع مشابه
Expression of the Aspergillus terreus itaconic acid biosynthesis cluster in Aspergillus niger
BACKGROUND Aspergillus terreus is a natural producer of itaconic acid and is currently used to produce itaconic acid on an industrial scale. The metabolic process for itaconic acid biosynthesis is very similar to the production of citric acid in Aspergillus niger. However, a key enzyme in A. niger, cis-aconitate decarboxylase, is missing. The introduction of the A. terreus cadA gene in A. niger...
متن کاملRelationship between morphology and itaconic acid production by Aspergillus terreus.
The morphology of filamentous fungi closely correlates with the productivity in submerged culture. Using itaconic acid (IA) production by Aspergillus terreus as a research model, the quantitative relationship between the growth form of A. terreus and IA production was investigated. IA fermentation was scaled up from shake flasks to a 7 L stirred tank bioreactor based on the quantitative relatio...
متن کاملBiosynthesis of itaconic acid in Aspergillus terreus. II. Early stages in glucose dissimilation and the role of citrate.
We have shown that crude, cell-free extracts of Aspergillus terreus contain aconitase and cis-aconitic decarboxylase, and therefore quantitatively decarboxylate cis-aconitic, citric, and d-isocitric acids to itaconic acid and CO2 (1, 2). With use of labeled substrates, it has been shown that the isotope distributions in itaconic acid are consistent with the formation of cis-aconitic acid from c...
متن کاملProduction of lovastatin and itaconic acid by Aspergillus terreus: a comparative perspective
Aspergillus terreus is a textbook example of an industrially relevant filamentous fungus. It is used for the biotechnological production of two valuable metabolites, namely itaconic acid and lovastatin. Itaconic acid serves as a precursor in polymer industry, whereas lovastatin found its place in the pharmaceutical market as a cholesterol-lowering statin drug and a precursor for semisynthetic s...
متن کاملDirectional Breeding of High Itaconic Acid Yielding Strain of Aspergillus terreus with a New Plate Technique
Itaconic acid is commercially produced by the cultivation of Aspergillus terreus using starch hydrolysate as carbon source. The degree of hydrolysis had a great influence on itaconic acid production which was suitable when corn starch was saccharified at 35 DE. The α-amylase was sufficient to drive the starch hydrolysis to the degree. The agar plate assay with LiCl treatment provided a rapid, s...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1957
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)70851-x